Change your USB selective suspend setting Run the Hardware and Device troubleshooter Uninstall the USB Driver in Device Manager Let’s not waste any more time and get to troubleshooting. Our article focuses on resolving the Device Descriptor Request Failed (Unknown USB device) issue in a timely manner, no matter what caused it. The issue at hand can be caused by either hardware or system-specific problems. This is a problem when you’re trying to use things such as a USB flash drive, memory card, Android device, game controller, or anything that plugs into your USB port. When you encounter this error message, you’re essentially told that the computer is unable to use the specific USB device connected. One of these common issues is the “ Unknown USB Device (Device Descriptor Request Failed) ” error that shows up in the Device Manager. Windows 10 Home users have been reporting issues when connecting and using a USB device on their computer.